Ah, the "plague and disease" genre. Truly, nothing quite says fun and lighthearted like infecting a virtual world with deadly viruses and wiping out entire populations. But hey, who said video games had to be all rainbows and unicorns? Despite the dark subject matter, players love this genre because it allows them to take on the role of a mastermind, strategizing and manipulating their way to global domination through sickness and death. It's like playing a twisted game of Risk, but instead of armies, you have infectious diseases at your disposal. And if you're looking for the top games in this genre, look no further! This site has curated a list of the best of the best, handpicked by experts with a sick sense of humor. So why not indulge your inner villain and see how far you can take your deadly germs? Just don't blame us when you start dreaming about pandemics every night.

Games like Resident Evil 4

Resident Evil 4

  • License: Commercial
  • Platforms: PC, PS2, Xbox 360, Console, iPhone / iPad, Wii, PS3, PS5, XSX, PS4, Wii U, Xbox One, Switch, Mac
  • Release: 2014
  • Rating: 9.1/10

Games like Resident Evil 2

Resident Evil 2

  • License: n/a
  • Platforms: PC, Console, PS4, XSX, PS5, Switch, Xbox One, PS3
  • Release: 2019
  • Rating: 9.1/10

Games like Neverwinter Nights

Neverwinter Nights

  • License: Commercial
  • Platforms: PC, Mac, iPhone / iPad, PS4, Switch, Xbox One
  • Release: 2002
  • Rating: 8.4/10

Games like SiN


  • License: commercial
  • Platforms: PC, Mac
  • Release: 1998
  • Rating: 7.2/10

Games like Syphon Filter 3

Syphon Filter 3

  • License: commercial
  • Platforms: Console, Android, PS5, PS4, PS3
  • Release: 2001
  • Rating: 6.8/10

Games like Scurge


  • License: commercial
  • Platforms: Console
  • Release: 2006
  • Rating: n/a